Gene information
Official symbol MTHFR
Official full name methylenetetrahydrofolate reductase
Gene type protein-coding gene
Chromosome1p36.22
Resources
Entrez Gene 4524
HGNC HGNC:7436
Ensembl ENSG00000177000
Vega OTTHUMG00000002277
UCSC uc001atc.3
GO terms: 45 records
GO Description Category LogP Number of genes Detail
GO:0001101 response to acid chemical GO Biological Processes -10.2965313 26 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001838 embryonic epithelial tube formation GO Biological Processes -6.74209917 20 More
GO:0001841 neural tube formation GO Biological Processes -5.20987525 16 More
GO:0001843 neural tube closure GO Biological Processes -4.06290305 13 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0006520 cellular amino acid metabolic process GO Biological Processes -2.20485551 9 More
GO:0006575 cellular modified amino acid metabolic process GO Biological Processes -7.43961662 26 More
GO:0006730 one-carbon metabolic process GO Biological Processes -1.95805030 3 More
GO:0006760 folic acid-containing compound metabolic process GO Biological Processes -2.40746524 3 More
GO:0006790 sulfur compound metabolic process GO Biological Processes -3.12963557 12 More
GO:0007584 response to nutrient GO Biological Processes -29.4823239 48 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0014020 primary neural tube formation GO Biological Processes -5.01152693 15 More
GO:0016053 organic acid biosynthetic process GO Biological Processes -15.6178787 26 More
GO:0016331 morphogenesis of embryonic epithelium GO Biological Processes -7.49308957 23 More
GO:0016491 oxidoreductase activity GO Molecular Functions -14.1519969 39 More
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors GO Molecular Functions -2.31840544 3 More
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor GO Molecular Functions -2.85684426 3 More
GO:0021915 neural tube development GO Biological Processes -7.57225811 24 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0033273 response to vitamin GO Biological Processes -22.1296854 31 More
GO:0035148 tube formation GO Biological Processes -7.32029616 23 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035999 tetrahydrofolate interconversion GO Biological Processes -3.88065666 3 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0042558 pteridine-containing compound metabolic process GO Biological Processes -2.12309907 3 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043200 response to amino acid GO Biological Processes -9.16129691 23 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0046394 carboxylic acid biosynthetic process GO Biological Processes -15.6974044 26 More
GO:0046653 tetrahydrofolate metabolic process GO Biological Processes -2.92766476 3 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0050660 flavin adenine dinucleotide binding GO Molecular Functions -1.96545001 9 More
GO:0050661 NADP binding GO Molecular Functions -1.63389635 6 More
GO:0060562 epithelial tube morphogenesis GO Biological Processes -17.7630248 53 More
GO:0060606 tube closure GO Biological Processes -4.01197458 13 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0072175 epithelial tube formation GO Biological Processes -6.28242122 20 More
GO:1901605 alpha-amino acid metabolic process GO Biological Processes -2.81275840 18 More
GO:1901607 alpha-amino acid biosynthetic process GO Biological Processes -2.12314076 8 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa00670 One carbon pool by folate KEGG Pathway -2.79007403 3 More
hsa01523 Antifolate resistance KEGG Pathway -5.90548425 6 More
Drug-Gene interaction
view
Related drugs: 25 records
Drug name Interaction type Source PMID View
albumin human NCI 11531629 view
alcohol NCI 15894672 view
benazepril PharmGKB 1608134315226090 view
bevacizumab PharmGKB 296621062063468919307503 view
capecitabine PharmGKB 2773834418245544177005932416759729845393278645921829961220819423279959891938429629134491233147362063892425331073203859952755714026967565234070492601492523736036 view
carbamazepine PharmGKB 12083967 view
carbidopa PharmGKB 12083967 view
carboplatin PharmGKB 216050042966210627995989206346891915990719307503 view
cisplatin PharmGKB 216050042966210627995989206346891915990719307503 view
clozapine PharmGKB 24725652 view
cyanocobalamin cofactor PharmGKB 2966210620634689119793471930750320589617 view
disulfiram PharmGKB 23335901 view
fluorouracil CIViCPharmGKB 277383441824554412083967177005932416759729845393278645921829961220819423279959891938429618704422291344912331473620638924253310732038599527557140249809462669307326967565234070492601492523736036 view
irinotecan NCI 16456808 view
leucovorin PharmGKB 1824554417700593298453932786459220819423291344912533107320385995275571402498094623407049 view
levodopa PharmGKB 12083967 view
mercaptopurine NCI 16614955 view
olanzapine PharmGKB 24725652 view
oxaliplatin NCIPharmGKB 161871121824554417700593298453932786459220819423291344912533107320385995275571402498094623407049 view
pemetrexed PharmGKB 29662106247321782063468919307503 view
phenobarbital PharmGKB view
phenytoin NCIPharmGKB 1208396710563481 view
pravastatin PharmGKB 18622257 view
sulfasalazine PharmGKB 12083967 view
warfarin NCI 14723717 view
Related studies: 14 records
Molecular factor Omics type Application Objective MI type Reference
NM_005957.5:c.665C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Inbal A et al. Blood. 1999
NM_005957.5:c.665C>T genomics myocardial infarction[diagnosis] myocardial infarction Nakai K et al. Coron Artery Dis. 2000
NM_005957.5:c.665C>T genomics myocardial infarction[diagnosis] myocardial infarction Virgos C et al. Clin Biochem. 2000
NM_005957.5:c.665C>T genomics myocardial infarction[diagnosis] myocardial infarction Gulec S et al. Clin Cardiol. 2001
NM_005957.5:c.665C>T genomics myocardial infarction[diagnosis] myocardial infarction Nishihama K et al. Int J Mol Med. 2007
NM_005957.5:c.665C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Celik M et al. Saudi Med J. 2008
NM_005957.5:c.665C>T genomics myocardial infarction[diagnosis] myocardial infarction Rallidis LS et al. Atherosclerosis. 2008
NM_005957.5:c.665C>T genomics infarct-related artery occlusion[prognosis (bad)] acute ST elevation myocardial infarction Patti G et al. J Thromb Thrombolysis. 2009
NM_005957.5:c.665C>T genomics acute anterior myocardial infarction[diagnosis] acute anterior myocardial infarction Ucar F et al. Arch Med Res. 2011
NM_005957.5:c.665C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Tomaiuolo R et al. J Transl Med. 2012
NM_005957.5:c.665C>T genomics myocardial infarction[diagnosis] myocardial infarction Sakowicz A et al. Biochem Genet. 2013
NM_005957.5:c.665C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Iqbal MP et al. Pak J Pharm Sci. 2016
NM_005957.5:c.665C>T genomics myocardial infarction[diagnosis] myocardial infarction Bandar IA et al. Probl Endokrinol (Mosk). 2007
NM_005957.5:c.1286A>C genomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Damar IH et al. Medeni Med J. 2020
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